Premier League Betting Guide for Matchweek 12

Manchester City have sustained their domination from 2017-18 into this season, but can we expect them to defeat Manchester United by more than one goal this weekend?

Matchweek 12 is sandwiched between UEFA Champions League and the international break, so there may be some squad rotation and tired legs in this week's matchups.

Using FanDuel's sportsbook as the source for lines, let's take a look at some bets you should zero in on this week.

Please note that lines are subject to change after this article is published, which impacts betting advice. All betting lines were taken from Paddy Power, and you cancheck here to see their most updated numbers.

Manchester City vs Manchester United

Manchester City -1 (+105)

Manchester United are off to a slow start by their lofty standards, sitting at 6W-2D-3L with a modest +1 goal differential. United are currently 7th in the table, and their star striker, Romelu Lukaku, is dealing with an injury that will likely leave him at less than 100% for the derby.

On the flip side, Manchester City have continued their dominance in the EPL and have been particularly dominant at home (6-0-0, +21 goal difference). City have won five of their six home games by more than one goal, and with Manchester United playing like a mid-table team at the moment, one would expect another easy win for Pep Guardiola’s side this weekend.

Crystal Palace vs Tottenham

Tottenham to Win (-130)

Tottenham have been a vastly superior side to Crystal Palace so far this season as they hold the edge in shots per game, shots conceded per game, possession and pass accuracy. Spurs are already 16 points clear of Palace in the table, and they are separated by 17 goals in terms of goal difference.

The one potential advantage that Palace possess in this game is home field, but even playing at home may not provide much of an edge. Palace have been a disappointing 0-2-3 at home this season, while Tottenham have started off 6-0-1 away from home.

Tottenham are clearly the superior side, and they have played better away from home this season, so they should be able to take care of business against Palace this weekend.

Cardiff vs Brighton

Cardiff to Win- Draw No Bet (-128)

Brighton are currently 12th in the table, having earned 14 points in 11 matches, but their decent start may be the result of some good fortune. Brighton are currently dead last in the league in both shots per game and shots on target per game, while also ranking 19th in shots conceded per game. Additionally, they check in 19th in possession per game and 18th in passing accuracy.

Cardiff are worse off in the league standings (currently 19th), but they do rank ahead of Brighton in shots, shots on target and shots conceded. Cardiff have also faced a daunting schedule so far this campaign, but they are a respectable 1-2-1 against teams in the bottom half of the table.

Cardiff’s difficult early schedule has buried them in the table, but they have shown an ability to earn results against bottom half teams. Given that Brighton has been less than stellar to start the year, Cardiff should be capable of earning a victory on their home soil.