Colts' Henry Anderson (knee) ruled out for Week 1 tilt with Lions

Indianapolis Colts defensive end Henry Anderson (knee) has been ruled out for Week 1 against the Detroit Lions.

What It Means:

As expected. Anderson is still working his way back from a torn ACL. With Anderson out, the Colts will now be without their best defensive lineman and best cornerback -- Vontae Davis. Top edge rusher Robert Mathis is 35 years old and Kendall Langford is also dealing with injuries. The Lions' Matthew Stafford is a strong play this week at quarterback.

Our algorithms project Stafford for 269 passing yards, 1.62 touchdowns, and 0.80 interceptions on 37 attempts in Week 1. The Colts' defense, once a matchup sleeper this week, are a fantasy unit to avoid. They rank 14th-best in our projections as of now, but that could slip. There are better options out there.