It's unfortunate news for the 2021 second-round pick, who missed a significant amount of time in the offseason with a foot/toe issue, and is now dealing with a concussion after Week 1.

Eskridge offers unique speed as a player and handled 2 designed carries for 22 yards, as well as 1 catch for 6 yards before leaving last Sunday's contest. He's a legitimate contender to be the Seahawks' WR3 behind Tyler Lockett and D.K. Metcalf whenever he's healthy. His absence this week could potentially open up more opportunities for tight end Gerald Everett, but the Seahawks might not have to pass often against the Titans' soft defense.

Mitchell got the nod in Week 1 after teammate Raheem Mostert suffered a season-ending knee injury, in part due to the team's decision to make 2021 third-round draft pick Trey Sermon a healthy scratch for their opening game. Sermon will now likely join the 49ers' active roster for Week 2, but is expected to operate as Mitchell's backup alongside JaMycal Hasty.

Mitchell has a $5,800 salary on FanDuel for Week 2 as the 49ers take on the Philadelphia Eagles, and is projected to finish the week with 10.4 fantasy points against a strong Eagles defensive line.

Penny left Week 1's win over the Indianapolis Colts with a calf injury that is expected to keep him sidelined for "a few weeks", so it's really more surprising that the team hasn't already ruled him out for Week 2. If Penny does sit out, expect the Seahawks to activate Alex Collins to be their primary backup running back come game time, while DeeJay Dallas and Travis Homer sprinkle in occasionally.

With Penny sidelined, Chris Carson projects to shoulder most of the running back workload for the Seahawks this week. He has a $6,700 salary on FanDuel for Week 2 and is projected to score 17.3 fantasy points against the Titans.

Michel saw just three snaps in his Rams debut in Week 1, with third-year back Darrell Henderson dominating snaps and touches for Los Angeles. Asked if Michel would have a larger role in Week 2, Sean McVary was noncommittal, stating "You have confidence that you can utilize him, if need be, but Darrell, I thought, did a great job. Darrell’s going to start the game. We want to really get him into the flow of it." He added additional praise for Henderson, saying "You do want to be able to say, ‘Hey, if we’re able to sustain drives, be able to get some things off, could you expect to see Sony?’ That’s a possibility, but Darrell’s a guy that’s done a really nice job and I was really pleased with how he got stronger as the game went on.” If McVay's words are to be believed, the Rams seem committed to continuing to feature Henderson in Week 2. Our models expect Henderson to handle 18.2 touches against the Colts.

Henderson's Week 2 projection includes 68.4 rushing yards, 13.5 receiving yards, 0.65 touchdowns, and 12.9 FanDuel points. His salary is $6,400 and he is the RB19 in our Week 2 rankings.

As expected, Williams has been ruled out of Week 2's clash with the Packers on Monday Night Football. He did not participate in practice at all during the week, and will not be available to face Green Bay on Monday. Quintez Cephus could see an increase in targets with Williams ruled out.

Cephus's Week 2 projection includes 3.3 receptions, 43.0 yards, 0.18 touchdowns, and 7.0 FanDuel points. His salary is $5,200.

Cole was limited at practice again on Friday and will carry the questionable tag into a Week 2 meeting with the Patriots. Jamison Crowder (groin) is also questionable after a week of limited practices. If Cole is active, our models expect him to see 2.1 targets in Week 2.

Cole's Week 2 projection includes 1.3 receptions, 15.1 yards, 0.08 touchdowns, and 2.6 FanDuel points.