Can San Francisco shut down Travis Kelce? Will Tyreek Hill's speed prove too much for the Niners? Here are five things to watch for that could decide the game.

Seattle's decimated running game may put the weight of the offense squarely on Russell Wilson's shoulders in this key clash.

Odell Beckham and Eli Manning are in a plum spot this week, taking on a struggling Saints defense in what's expected to be a high-scoring game. Which other stacks should you look into for Week 4?

Pat Mahomes should keep rolling this week, giving his pass-catchers plenty of fantasy upside, as well. What other offenses should you stack?

LeSean McCoy took advantage of a juicy matchup, dominating the Cleveland Browns. Which other players helped their teams the most in Week 15?