Will Jimmy Garoppolo take the reins for the 49ers in the season opener, or will Kyle Shanahan be ready to turn the team over to rookie Trey Lance?

Which rookies should you be targeting in your fantasy football rookie drafts this season?

Sermon has a chance to be productive as a rookie in a solid San Francisco offense. What kind of numbers could he produce?

Lance offers a big-time fantasy-football ceiling but isn't without flaws. How will he fare with the 49ers?

The Dallas Cowboys get not only Dak Prescott back in 2021 but also key pieces along the offensive line. How does that impact their betting outlook?

Which NFC skill-position players could be cap casualties this offseason?

Who are the biggest risers and fallers in numberFire's power rankings this week?

San Francisco 49ers offensive tackle Trent Williams (elbow) is ruled out for Week 17's game against the Seattle Seahawks.

San Francisco 49ers wide receiver Brandon Aiyuk (ankle) won't play in Week 17 against the Seattle Seahawks, per head coach Kyle Shanahan.

San Francisco 49ers tight end George Kittle (foot) is officially active for the team's Week 16 game against the Arizona Cardinals.

San Francisco 49ers quarterback Nick Mullens (elbow) was placed on injured reserve on Friday.

San Francisco 49ers tight end George Kittle (foot) was activated from injured reserve on Thursday.